HIDDEN AGENDA - THE INVOLVEMENT OF ENDOPLASMIC RETICULUM STRESS AND UNFOLDED PROTEIN RESPONSE IN INFLAMMATION-INDUCED MUSCLE WASTING

Hidden Agenda - The Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response in Inflammation-Induced Muscle Wasting

Critically ill patients at the intensive care unit (ICU) often develop a generalized weakness, called ICU-acquired weakness (ICUAW).A major contributor to ICUAW is muscle atrophy, a loss of skeletal muscle mass and function.Skeletal muscle assures almost all of the vital functions of our body.It adapts rapidly in response to physiological as well a

read more


Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival

IntroductionCentral to allograft rejection is the T cell-mediated adaptive immune response initiated by activated dendritic cells (DCs).Previous studies have shown that the DNA-dependent activator of IFN regulatory factors (DAI) is involved in the maturation and activation of DCs.Therefore, we hypothesized that inhibition of BELTS DAI could prevent

read more